How is vesicant chemotherapy administered?
Peripheral vesicants are administered by gravity infusions or i.v. bolus and should not be infused using an infusion pump since the pump may continue to deliver a vesicant into the tissue until the pump alarm is triggered (AIII).
What is the safest way to administer vesicant therapy?
If there is any doubt, don’t use the catheter for vesicant infusions. Prevention is key, as there are no viable or reliable treatments for most vesicant extravasations. The Infusion Nurse Society Standards of Practice mandate that continuous vesicant infusions should be administered through a central venous catheter.
What route is the best for the administration of chemotherapeutic drugs that are vesicants?
A vesicant drug that is supplied in a syringe must be administered by IV push via the sidearm of a primary IV line flowing freely at all times by gravity maintaining a closed system using a CSDTD. 3. A vesicant drug that is supplied in a minibag and given via a Central Venous Access Device may be infused using a pump.
Which chemotherapy drugs are vesicant?
Vesicants: Drugs that can result in tissue necrosis or formation of blisters when accidentally infused into tissue surrounding a vein[14]. They include Actinomycin D, Dactinomycin, Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Mitomycin C, Vinblastine, Vindesine, Vincristine, and Vinorelbine.
When administering a vesicant drug as a bolus you should?
If there is more than one vesicant drug, administer DNA binding drugs first followed by non DNA binding drugs e.g. anthracyclines followed by vinca alkaloids. During the administration of a vesicant drug: for bolus infusions staff should remain at the patient’s side during the entire administration.
What IV drugs are vesicants?
IV Extravasation – Vesicant Medications
- Acyclovir > 7mg/mL (Zovirax®)
- Aminophylline.
- Calcium salts ( 100 mg/mL concentration)
- Chlorothiazide (Diuril®)
- Cisplatin (Platinol®)(in concentrations 0.5 mg/mL)
- Dactinomycin (Actinomycin-D, Cosmegen®)
- Daunorubicin (daunomycin, Cerubidine®)
- Dextrose solutions >10%
Which route of administration is considered the safest route for a vesicant drug or solution?
Vincristine (a vinca alkaloid and vesicant) must only be administered intravenously. Sentinel events resulting in permanent disability or death from inadvertent intrathecal administration of vinca alkaloids are well documented.
What are the route in administering chemotherapy?
Chemotherapy is most often given as an infusion into a vein (intravenously). The drugs can be given by inserting a tube with a needle into a vein in your arm or into a device in a vein in your chest.
How are Antineoplastics administered?
Intravenous anti-cancer drugs may be administered through a central venous access device (CVAD) or peripheral cannula. Administration may be via bolus injection, intermittent infusion or continuous infusion as determined by the treatment protocol.
Is Taxol a vesicant or irritant?
Chemotherapy vesicant & irritant properties and suggested management for extravasation
| Drug | Vesicant or Irritant |
|---|---|
| Paclitaxel (Taxol) | Irritant (usually) Vesicant (rare) |
| Paclitaxel, nanoparticle albumin-bound (Abraxane) | Irritant |
| Plicamycin (Mithracin) | Vesicant/Irritant (depending on reference) |
| Raltitrexed (Tomudex) | Irritant |
What is the correct order of intravenous administration of antineoplastic drugs?
Correct order of intravenous administration of antineoplastic drugs should be as follows (unless otherwise indicated by the specific treatment protocol): Irritant, vesicant, non irritant, neutral.
What is an example of a vesicant?
Vesicants include distilled mustard (HD), mustard gas (H), lewisite, mustard/lewisite, mustard/T, nitrogen mustard, phosgene oxime, sesqui mustard, and sulfur mustard.