What are the factors that affect drug actions?
Factors that. Influence Drug. Effects.
What are the physiological factors affecting drug absorption?
Physiological Factors Affecting Absorption
- Gastric motility. It has large effect.
- Ionization and gastric emptying.
- Splanchnic blood flow.
- Enterohepatic circulation.
- Metabolism of drug.
- Pharmacogenetic factors.
- Disease state.
- Route of administration.
What are the 4 factors that can affect drug distribution?
Drug distribution is affected by many factors, including plasma or tissue protein binding, body weight, body composition, and body fluid spaces (8). Of these, total body weight, muscle mass, and fat composition are the major determinants of drug distribution, and women may differ from men in both of these factors.
How does body size affect drug action?
As clearance determines a drug’s maintenance dose, clinicians should consider how lean body weight, rather than total body weight, impacts dosing. When lean body weight increases there will be a corresponding increase in drug clearance and an increased dose may be required.
What are the personal factors that contribute to substance?
There are certain factors that increase the risk of a person developing an addiction to drugs or alcohol. Genetics, family history, mental health, and the environment are some of the risk factors for addiction susceptibility.
What are the factors that influence the effects of drugs on human body?
The main factors are disease, genetics, and age. Nutritional status, sex, hormonal status (e.g., the effects of pregnancy), and circadian rhythm have important influences. Maternal toxicity will affect the fetus. The absorption and excretion of drugs are frequently reduced by diseases.
What are the four main drug actions?
Think of pharmacokinetics as a drug’s journey through the body, during which it passes through four different phases: absorption, distribution, metabolism, and excretion (ADME).
How do drugs act on the body?
The drugs that enter an individual tend to stimulate certain receptors, ion channels, act on enzymes or transport proteins. As a result, they cause the human body to react in a specific way. Based on drug action on receptors, there are 2 different types of drugs: Agonists – they stimulate and activate the receptors.