What is thyrotoxicosis storm?
Thyroid storm, also referred to as thyrotoxic crisis, is an acute, life-threatening, hypermetabolic state induced by excessive release of thyroid hormones (THs) in individuals with thyrotoxicosis. Thyroid storm may be the initial presentation of thyrotoxicosis in undiagnosed children, particularly in neonates.
What is thyrotoxic crisis or storm?
Thyroid storm (thyrotoxic crisis): Thyroid storm is a rare and life-threatening condition that happens when your thyroid suddenly produces and releases large amounts of thyroid hormone. It’s usually caused by a sudden event or illness such as surgery or an infection.
What is the pathophysiologic basis of thyroid storm?
Any primary cause of hyperthyroidism can escalate into thyrotoxic crisis. There are triggers that can induce thyroid storm in patients with unrecognized thyrotoxicosis, which includes nonthyroidal surgery, parturition, major trauma, infection, or iodine exposure from radiocontrast dyes or amiodarone [27].
What is the most common cause of thyroid storm?
Thyroid storm is more likely to develop when a person has a serious health problem in addition to hyperthyroidism or in people who have untreated or undertreated Graves’ disease. The problem usually happens after a stressful event or a serious illness, such as a major infection.
What are the effects of Thyrotoxic crisis?
A thyroid storm — or thyroid crisis — can be a life-threatening condition. It often includes a rapid heartbeat, fever, and even fainting. Your thyroid is a master at managing your body. The hormones produced by this gland located at the base of your neck help control your metabolism.
What are the symptoms of thyrotoxicosis?
Symptoms of overt thyrotoxicosis include heat intolerance, palpitations, anxiety, fatigue, weight loss, muscle weakness, and, in women, irregular menses. Clinical findings may include tremor, tachycardia, lid lag, and warm moist skin.
What is the management of thyroid storm?
High-dose propylthiouracil (PTU) or methimazole may be used for treatment of thyroid storm. PTU has a theoretical advantage in severe thyroid storm because of its early onset of action and capacity to inhibit peripheral conversion of T4 to T3.
What is Thyrotoxic?
Thyrotoxicosis means an excess of thyroid hormone in the body. Having this condition also means that you have a low level of thyroid stimulating hormone, TSH, in your bloodstream, because the pituitary gland senses that you have? enough? thyroid hormone.
What happens to your body during a thyroid storm?
Which patient is most at risk for thyroid storm?
Age
- Thyroid storm may occur at any age but is most common in those in their third through sixth decades of life.
- Graves disease predominantly affects those aged 20-40 years.
- The prevalence of toxic multinodular goiter increases with age and becomes the primary cause of hyperthyroidism in elderly persons.
What is treatment for thyroid storm?
Who is at risk for thyrotoxicosis?
Risk factors for hyperthyroidism, include: A family history, particularly of Graves’ disease. Female sex. A personal history of certain chronic illnesses, such as type 1 diabetes, pernicious anemia and primary adrenal insufficiency.
What is thyroid storm?
No drug references linked in this topic. Thyroid storm is a rare, life-threatening condition characterized by severe clinical manifestations of thyrotoxicosis [ 1 ].
What is the prevalence of storm in patients with thyrotoxicosis?
In the United States survey, 16 percent of inpatients with thyrotoxicosis were diagnosed with storm [ 4 ]. It may be precipitated by an acute event such as thyroid or nonthyroidal surgery, trauma, infection, an acute iodine load, or parturition.
What is the mortality associated with thyroid storm?
The mortality associated with thyroid storm is estimated to be 8-25% despite modern advancements in its treatment and supportive measures.[1] Thus, it is very important to recognize it early and start aggressive treatment to reduce mortality.
What is the approach to the treatment of thyroid storm?
The approach to treatment of thyroid storm includes the following: Patients with contraindications to thionamides need to be managed with supportive measures, aggressive beta blockade, iodine preparations, glucocorticoids, and bile acid sequestrants for about a week in preparation for a thyroidectomy.