How do you infuse voriconazole?
VFEND I.V. for Injection requires reconstitution to 10 mg/mL and subsequent dilution to 5 mg/mL or less prior to administration as an infusion, at a maximum rate of 3 mg/kg per hour over 1 to 3 hours. Administer diluted VFEND I.V. by intravenous infusion over 1 to 3 hours only.
Can you cut voriconazole tablets?
Although voriconazole film-coated tablets are not that easy to divide in half, as they are not scored, and also the manufacturer has mentioned that the tablets should be swallowed whole, it seems that dividing voriconazole tablets will not change the bioavailability and the clinical exposure is almost the same (5).
Does voriconazole need to be refrigerated?
Store voriconazole powder for oral suspension in a refrigerator at 36°F to 46°F (2°C to 8°C) before reconstitution. After reconstitution, the oral suspension should be stored at 59°F to 86°F (15°C to 30°C). Do not refrigerate or freeze it.
Who manufactures voriconazole?
VFEND®(voriconazole) | Pfizer Medical Information – US.
What is voriconazole 200mg?
Voriconazole is used to treat serious fungal or yeast infections, such as aspergillosis (fungal infection in the lungs), candidemia (fungal infection in the blood), esophageal candidiasis (candida esophagitis), or other fungal infections (infections in the skin, stomach, kidney, bladder, or wounds).
What is voriconazole dosing?
Adults weighing less than 40 kilograms (kg)—At first, a loading dose of voriconazole injection is given by your doctor on the first 24 hours of treatment. Then, your doctor may switch you to an oral maintenance dose of 100 or 150 milligrams (mg) taken every 12 hours. Your doctor may adjust your dose as needed.
Why is voriconazole hazardous?
The most common adverse effects reported with clinical use of voriconazole include visual disturbances, elevations of liver function tests and skin rash. Voriconazole has been associated with photosensitivity skin reactions especially during long term therapy. at the highest dose used in the test.
How quickly does voriconazole work?
Steady-state levels are attained after 5–6 days when 3–6 mg/kg/day of voriconazole is administered. However, intravenous loading doses reduce the time to reach steady state to only 1 day. Similarly, oral loading doses also lead to achievement of steady-state levels within 24 hours.
How long is voriconazole treatment?
Treatment duration should be as short as possible depending on the patient’s clinical and mycological response. Long term exposure to voriconazole greater than 180 days (6 months) requires careful assessment of the benefit-risk balance (see sections 4.4 and 5.1).
How long is a course of voriconazole?
Voriconazole is the drug of choice for IPA1. The recommended treatment duration is a minimum of 6–12 weeks, although there is little evidence for the optimal treatment duration3.
Is voriconazole available in generic?
Glenmark is marketing its generic voriconazole tablets in the same 50 mg and 200 mg dosage strengths as brand-name Vfend.
What is the cost of Vfend?
On average, the cash price of Vfend is $196.59 for 2, 200MG Tablet. The price of Vfend may vary, however, depending on the strength, quantity, and formulation prescribed. With a free coupon for Vfend from SingleCare, generic Vfend may cost only $56.70 for 30, 200MG Tablet.