Can abnormal cells come back after LEEP?
A LEEP procedure is exceptionally effective at removing any abnormal or precancerous cells from your cervix. However, depending upon your individual situation, it is possible that abnormal cells will return again, which is why we want to have follow-up appointments and regular cervical cancer screenings with you.
What happens if you have positive margins after LEEP?
A positive margin after LEEP (defined as a histopathological finding of CIN along the specimen margin regardless of the CIN grade) is a well-defined predictor of persistent/recurrent disease [4, 11, 12, 14].
Do you still have HPV after LEEP procedure?
Background. About 23% of patients develop CIN2+ after LEEP treatment due to residual or recurrent lesions. The majority of patients with HPV infection were HPV negative before treatment, but 16,4% were still HPV 16 positive after treatment, indicating that conization do not necessarily clear HPV infection rapidly.
Is a second LEEP procedure common?
3.2% (7 patients) were diagnosed with HSIL and underwent a second LEEP. This study found that 14.0% of patients (n = 31) required further follow up based on findings at the second colposcopy follow up visit.
What are the chances of CIN 2 returning?
Five-year risks of recurrent CIN2+ after treatment varied both by antecedent screening test result and the histology of the treated lesion. The risk ranged from 5% for CIN2 preceded by HPV-positive/ASC-US or LSIL to 16% for CIN3/AIS preceded by AGC/ASC-H/HSIL+ (p<0.0001).
Why does HPV keep coming back?
The most common reason for cell changes to come back would be your immune system not getting rid of high-risk HPV. We don’t yet know why some people can clear HPV and others can’t.
What does clear margins mean?
A clear, negative, or clean margin means there are no cancer cells at the outer edge of tissue that was removed. A positive margin means that cancer cells come right out to the edge of the removed tissue and have ink on them.
Why do I need a second LEEP procedure?
In some cases, abnormal cells are found again. If this happens, you may require another LEEP. Following a normal Pap and negative HPV test, patients are required to come back a year later for another screening.
Can HPV come back after cleared?
Several studies involving younger women indicate that type-specific HPV can be detected again after a long period of apparent clearance, but it has not been established whether type-specific HPV redetection is due to reactivation of a low-level persistent infection or the result of a new infection [6–9].
Can you clear persistent HPV?
Most cases of HPV infection tend to be cleared by the immune system without intervention 1–2 years post-exposure; it is thought that persistent infection is most likely due to a lack of HPV-specific T-cell immunity [74].
How often do you need a second LEEP?
Following a normal Pap and negative HPV test, patients are required to come back a year later for another screening. Women with high-grade dysplasia who undergo a LEEP need to be followed closely for 25 years to make sure it does not recur.
Is a LEEP curative?
Purpose of a LEEP Procedure While a LEEP can remove abnormal cervical cells, it is not a cure for HPV. Even if the cells are cleared, you will still have HPV and require ongoing monitoring to ensure that any abnormal cells are treated promptly if and when they emerge.
Did your first PAP come back abnormal after A leep?
Just found out that my first pap after a Leep came back abnormal. My leep results did show unclear margins, but the doctor thought those cells on the margin would be destroyed when she cauterized the site. Seems that did not happen. I go back for another colposcopy in June and start this whole process over again.
Can you have abnormal cells after a LEEP procedure?
Can You Have Abnormal Cells After a LEEP Procedure? Whenever abnormal cells are found during a Pap test , you may be anxious—after all, a Pap smear is one of the most effective methods of detecting cervical cancer at its earliest, and most treatable stage. If you have abnormal cells, there are a number of responses.
What happens if I have abnormal cells in my Pap smear?
If you have abnormal cells, there are a number of responses. The next step depends upon your age, the results of your previous Pap smears, and the degree of change seen on your current Pap.
What is the next step after a Pap smear?
The next step depends upon your age, the results of your previous Pap smears, and the degree of change seen on your current Pap.