Can dermatomyositis cause liver damage?

Abstract. Background Long-term use of hormones and immunosuppressive agents is necessary for treating polymyositis (PM)/dermatomyositis (DM) but may cause liver damage.

Does myositis affect the liver?

Inflammatory myositis is sometimes wrongly diagnosed as liver disease, delaying appropriate treatment. In the assessment of PM, attention should be drawn to the rise in serum alkaline phosphatase in view of the possible association between the two diseases (1-4).

What is the life expectancy of dermatomyositis?

For dermatomyositis, polymyositis, and necrotizing myopathy, the progression of the disease is more complicated and harder to predict. More than 95 percent of those with DM, PM, and NM are still alive more than five years after diagnosis.

Is Dermatopolymyositis a cancer?

Polymyositis and DM symptoms can be a sign of existing cancer or may also increase the risk of malignancy. The most common cancers described in cancer associated dermatomyositis (CADM) are: breast cancer, lung, ovary, stomach, intestine, nasal cavity, throat, pancreatic, bladder and Hodgkin’s lymphoma [1–3].

What are the symptoms of myositis?

Early symptoms in patients with myositis include:

• Difficulty standing up from a seated position.
• Difficulty climbing stairs.
• Difficulty lifting the arms.
• Fatigue after standing or walking a long time.
• Trouble swallowing or breathing.
• Muscle pain that does not subside within a few weeks.

What is Polymyopathy?

Overview. Polymyositis (pol-e-my-o-SY-tis) is an uncommon inflammatory disease that causes muscle weakness affecting both sides of your body. Having this condition can make it difficult to climb stairs, rise from a seated position, lift objects or reach overhead.

How does autoimmune disease affect the liver?

Autoimmune liver diseases occur when the body’s immune system attacks the liver, causing inflammation. If left untreated, the liver inflammation may eventually cause cirrhosis of the liver, which may lead to liver cancer and liver failure.

How long can you live with autoimmune hepatitis?

Without treatment, approximately 40% to 50% of the individuals with severe disease will die within 6 months to 5 years. Treatment with steroids has dramatically changed the course of the disease. Most patients respond to therapy and the 10-year survival rate is approximately 83.8% to 94%.

Does dermatomyositis shorten your life?

Dermatomyositis and polymyositis are serious diseases with a disease‐related mortality of at least 10%. In the long term, myositis has a major effect on perceived disability and quality of life, despite the regained muscle strength.

What is the death rate of dermatomyositis?

Previous studies reported that the connective tissue disease PM/DM has a poor prognosis and high I-HMR. The reported 10-year survival rate ranged between 53% and 91% [4, 9–12]. A very recent population-based study from America reported a hospital mortality of 4.5% [2].

Can dermatomyositis lead to cancer?

Cancer-associated myositis occurs most frequently for patients with dermatomyositis. (It has been estimated that as much as 20-30% of DM patients will develop cancer.) Those with polymyositis develop cancer about half as frequently as those with dermatomyositis.

What percentage of adult patient with dermatomyositis have an associated malignancy?

The incidence of malignancy in DM patients was 8.83% (65/736). Most malignancies were detected in the most recent 1 year before (9/65, 13.85%) or within 3 years after (40/65, 61.54%) the onset of DM. Males (35/65, 53.85%) and patients aged between 50 and 69 years (43/65, 66.15%) were prone to develop malignancies.