Is it safe to take simvastatin with amlodipine?
In summary, the available evidence supports the recommendation that the maximum daily dose of simvastatin should not exceed 20 mg when co-administered with amlodipine or diltiazem: concomitant use of either amlodipine or diltiazem increases the exposure to simvastatin through CYP3A4 interactions.
Can you take statins with amlodipine?
The Food and Drug Administration has enforced that people taking simvastatin with amlodipine should take a maximum dose of no more than 20 mg because of the risk of myopathy. No dose limitation has been suggested for patients taking atorvastatin while they are also taking amlodipine [2].
What drugs should not be taken with amlodipine?
A doctor may also prescribe amlodipine for coronary artery disease and angina….Amlodipine can potentially interact with some other medications, including:
- Simvastatin. The FDA recommends limiting the dosage of simvastatin to 20mg daily while also taking amlodipine.
- CYP3A4 inhibitors.
- Cyclosporine.
Which statins interact with amlodipine?
There is no evidence of significant interaction when amlodipine is coadministered with atorvastatin, pitavastatin, rosuvastatin, fluvastatin, and pravastatin, and combination therapy may be considered.
What amlodipine has been recalled?
An MHRA statement said: “The MHRA has confirmed that the recall of combined Amlodipine/Olmesartan Medoxomil tablets 10 mg/20 mg, batch number BAD62101A (expiry Feb 24), is for the US market only – while Macleods Pharma does supply other medicines to the UK, this particular product is not available here.”
What medications should not be taken with simvastatin?
Do not use simvastatin if you are also taking boceprevir (Victrelis®), cobicistat-containing products (Stribild®), cyclosporine (Gengraf®, Neoral®, Sandimmune®), danazol (Danocrine®), gemfibrozil (Lopid®), nefazodone (Serzone®), telaprevir (Incivek®), certain antibiotics (eg, clarithromycin, daptomycin, erythromycin.
Can you take statins and blood pressure tablets at the same time of day?
Researchers say prescribing statins along with blood pressure medications improves the survival odds for people with hypertension. The number of deaths from stroke and heart disease could significantly decrease if people are given statins in combination with medications that lower blood pressure.
Can you take cholesterol medicine and blood pressure medicine at the same time?
Taking daily doses of two blood pressure drugs (fixed dose candesartan and hydrochlorothiazide) along with a cholesterol-lowering drug (low-dose rosuvastatin), proved to be the most effective, cutting first-time strokes by 44 percent among patients at intermediate risk for heart disease.
Why should amlodipine be taken at night?
New research suggests that taking your blood pressure medication at bedtime may more effectively reduce your risk of illness or death due to heart and blood vessel disease. Timing of medication is important because blood pressure follows a daily rhythm. It rises higher during the day and falls at night when we sleep.
Is there a problem with amlodipine?
It comes with serious risks if you don’t take it as prescribed. If you don’t take it at all or stop taking it: If you don’t take amlodipine or stop taking it, your blood pressure or chest pain may get worse. This could lead to serious problems, such as a stroke or heart attack.
Why you should not take amlodipine?
Conditions: severe narrowing of the aortic heart valve. significantly low blood pressure. severe liver disease.