What cells express Prox1?
Prox1 is expressed in slow muscle fibres and SC
- Figure 1: Prox1 expression in slow muscle fibres in mammalian skeletal muscle.
- Figure 2: Prox1 is expressed in rodent and human satellite cells.
- Figure 3: Prox1 regulates the slow muscle fibre gene program in skeletal muscle.
Is Pu 1 a transcription factor?
PU. 1, encoded by the Spi1 gene, is an ETS-family transcription factor with multiple roles in hematopoiesis. It is a lineage-specifying transcription factor that positively regulates many genes in the macrophage, granulocyte, dendritic-cell and B-cell lineages.
Does p53 act as a transcription factor?
Abstract. p53 is a transcription factor that suppresses tumor growth through regulation of dozens of target genes with diverse biological functions.
What are enhancers and silencers?
A cis-regulatory sequence that increases the activity of a gene when bound by transcription factors is called an enhancer, while a sequence that causes a decrease in gene activity is called a silencer.
What is Cebpa gene?
Collapse Section. The CEBPA gene provides instructions for making a protein called CCAAT enhancer-binding protein alpha. This protein is a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity (expression) of certain genes.
Where are transcription factors synthesized?
the nucleus
Nuclear localization. In eukaryotes, transcription factors (like most proteins) are transcribed in the nucleus but are then translated in the cell’s cytoplasm. Many proteins that are active in the nucleus contain nuclear localization signals that direct them to the nucleus.
What kind of transcription factor is p53?
Is p53 a transcription factor for p21?
As a bona fide transcription factor, p53 transactivates its target genes in response to these stresses, resulting in cell-cycle arrest, senescence, or apoptosis, to prevent the proliferation of damaged cells. The best known examples of such targets include p21 and MDM2.
What is enhancers and silencers in transcription?
What is silencer in transcription?
Silencers are regulatory DNA elements that reduce transcription from their target promoters; they are the repressive counterparts of enhancers. Although discovered decades ago, and despite evidence of their importance in development and disease, silencers have been much less studied than enhancers.
What is the function of Cebpa?
Normal Function The CEBPA gene provides instructions for making a protein called CCAAT enhancer-binding protein alpha. This protein is a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity (expression) of certain genes.