What does FGF2 bind to?

FGF2 binding phosphorylates both extracellular signal-related kinase (ERK) and focal adhesion kinase (FAK), although not necessarily through the same signaling pathway [9,10].

Where is FGF2 located?

FGF2 overexpression up-regulates the production of biologically active osteopontin in endothelial cells. The expression of basic fibroblast growth factoR (bFGF) gene could be found in the skin from all developmental stages in mice.

What does fibroblast growth factoR do?

Fibroblast growth factors (FGFs) that signal through FGF receptors (FGFRs) regulate a broad spectrum of biological functions, including cellular proliferation, survival, migration, and differentiation.

What is FGFR1 gene?

The FGFR1 gene is involved in a type of blood cancer called 8p11 myeloproliferative syndrome. This condition is characterized by an increased number of white blood cells (myeloproliferative disorder) and the development of lymphoma, a blood-related cancer that causes tumor formation in the lymph nodes.

What is human FGF2 gene?

FGF2 (Fibroblast Growth Factor 2) is a Protein Coding gene. Diseases associated with FGF2 include Corneal Neovascularization and Chronic Ulcer Of Skin. Among its related pathways are MET promotes cell motility and Cytokine Signaling in Immune system.

How many FGF receptors are there?

four members
The human fibroblast growth factor receptor (FGFR) family consists of four members: FGFR1 to FGFR4.

What does the FGF2 gene do?

FGF2 Gene – Fibroblast Growth Factor 2 FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth.

What is the receptor for FGF2?

FGF2 signals through four receptor tyrosine kinases (FGF receptor 1 through FGF receptor 4) and acts in a variety of developmental processes, including angiogenesis.

What does FGF 23 do?

The FGF23 gene provides instructions for making a protein called fibroblast growth factor 23, which is produced in bone cells. This protein is necessary in regulating the phosphate levels within the body (phosphate homeostasis).

What stimulates VEGF production?

VEGF-A production can be induced in a cell that is not receiving enough oxygen. When a cell is deficient in oxygen, it produces HIF, hypoxia-inducible factor, a transcription factor. HIF stimulates the release of VEGF-A, among other functions (including modulation of erythropoiesis).

Is FGFR1 a tyrosine kinase?

Fibroblast growth factor receptor 1 (FGFR1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and CD331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family.

How does FGFR3 mutation cause achondroplasia?

Abstract. FGFR3 gain-of-function mutations lead to both chondrodysplasias and craniosynostoses. Achondroplasia (ACH), the most frequent dwarfism, is due to an FGFR3-activating mutation which results in impaired endochondral ossification. The effects of the mutation on membranous ossification are unknown.

What is the sequence of the FGF2 protein?

FGF2 Protein Sequence Species Human FGF2 protein Mouse FGF2 protein Rat FGF2 protein Length 288 154 154 Mass (Da) 30770 17153 17139 Sequence Human FGF2 protein sequence Mouse FGF2 protein sequence Rat FGF2 protein sequence

What is the function of FGF2 in the body?

FGF2 has been implicated in a multitude of physiologic and pathologic processes, including limb development, angiogenesis, wound healing, and tumor growth (summary by Ortega et al., 1998). Belongs to the heparin-binding growth factors family.

What is fibroblast growth factor 2 (FGF2)?

The fibroblast growth factor 2 (FGF2) is a potent mitogenic factor belonging to the FGF family. It plays a role in airway remodeling associated with chronic inflammatory airway diseases, including asthma and chronic obstructive pulmonary disease (COPD).

What is the role of frs2alpha in fibroblast growth factor regulation?

FRS2alpha is essential for the fibroblast growth factor to regulate the mTOR pathway and autophagy in mouse embryonic fibroblasts. Int. J.