What does NS1 negative mean?
A positive NS1 test result confirms dengue virus infection without providing serotype information. A negative NS1 test result does not rule out infection. People with negative NS1 results should be tested for the presence of dengue IgM antibodies to determine possible recent dengue exposure.
Is low platelet normal in dengue?
Dengue fever can result in a drop in your white blood cell and platelet counts. The normal platelet count in the body ranges from 1.5 to 4 lacs, this can go down to as low as 20,000 to 40,000 in the case of dengue patients.
How dengue virus causes low platelet count?
When an infected mosquito bites a human, the dengue virus enters the bloodstream, it binds to platelets and replicates leading to multiplication of infectious virus. The infected platelet cells tend to destroy normal platelets which is one of the major causes for the drop in the platelet count in dengue fever.
What is the lowest platelet count in dengue?
A typical person has a platelet count of between 150,000 and 250,000 per microlitre of blood. About 80 to 90 per cent of patients with dengue will have levels below 100,000, while 10 to 20 per cent of patients will see critically low levels of 20,000 or less.
What is the confirmatory test for dengue?
Nucleic acid amplification tests (NAATs) Presence of virus by rRT-PCR or NS1 antigen in a single diagnostic specimen is considered laboratory confirmation of dengue in patients with a compatible clinical and travel history.
What is dengue IgG negative?
Negative tests for IgM and/or IgG antibodies may mean that the individual tested does not have a dengue infection and symptoms are due to another cause, or that the level of antibody may be too low to measure.
On which day platelets increase in dengue?
Higher platelet count at presentation was associated with early recovery time (p<0.033). Of 108(78%) patients who presented with platelet count of 20,000-<50,000/mm3, platelet count of 36(33.33%) rose to >50,000/mm3 within 2 days, and 62(57.4%) rose to >50,000 in 3-5 days.
How many days platelets increase in dengue?
Mean spontaneous platelet recovery time was 3±2.6 days and 3±1.87 days in primary and secondary infection respectively. Higher platelet count at presentation was associated with early recovery time (p<0.033).
What is the critical stage of dengue?
The critical phase of dengue begins at defervescence and typically lasts 24–48 hours. Most patients clinically improve during this phase, but those with substantial plasma leakage can, within a few hours, develop severe dengue as a result of a marked increase in vascular permeability.
What is difference between dengue NS1 and IgM?
NS1 antigen is generally found during Day 1 and up to Day 9 after onset of fever. The detection of anti-NS1 is inhibited if anti-NS1 antibodies produced. Whereas IgM become detectable by Day 3 to Day 5 after onset of illness in primary dengue and by Day 1 to Day 2 after onset of illness in secondary infections.
Can CBC test detect dengue?
The clinical presentation of dengue patients is acute febrile illness with no localizing signs and symptoms which may mimic other infections. Therefore the laboratory tests such as a complete blood count (CBC), serological test or blood culture need to be used to differential and confirm the diagnosis.
What is the medical use of NS1 antigens?
Medical use. NS1 is present in the serum of infected persons directly at the onset of clinical symptoms in primary dengue infection and produces a strong humoral response. It is detectable before the appearance of IgM antibodies. DENV by NS1 antigen is laboratory confirmation of dengue in people also assessing clinical aspects (as well as,…
What does a negative NS1 test result mean?
Interpretation of results A positive NS1 test result confirms dengue virus infection without providing serotype information. A negative NS1 test result does not rule out infection. People with negative NS1 results should be tested for the presence of dengue IgM antibodies to determine possible recent dengue exposure.
Can NS1 be found in blood or plasma?
Though studies show that NS1 can be found in whole blood or plasma, most NS1 tests have been developed and evaluated in serum samples.
Is platelet count associated with NS1 and IgM/IgG in dengue infections?
The newer parameter NS1 appears to be highly specific and reliable for diagnosis of dengue infection from the first day of fever. Platelet count is the only accessory test for diagnosis of dengue infection in the peripheral laboratories. Therefore, we tried to evaluate the association of platelet counts against NS1 and IgM/IgG in dengue infections.