What does the SH3 domain bind to?
The SH3 domain is a distinct motif that binds target proteins, including proteins associated with the actin cytoskeleton, through sequences containing proline and hydrophobic amino acids.
What proteins have an SH3 domain?
The SH3 proteins interact with adaptor proteins and tyrosine kinases. Interacting with tyrosine kinases, SH3 proteins usually bind far away from the active site. Approximately 300 SH3 domains are found in proteins encoded in the human genome….SH3 domain.
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What is SH2 and SH3 domains?
SH2 domains bind to short phosphotyrosine-containing sequences in growth factor receptors and other phosphoproteins. SH3 domains bind to target proteins through sequences containing proline and hydrophobic amino acids.
How does SH3 domain recognize proline?
We conclude that SH3 domains recognize proline-rich motifs possessing the left-handed type II polyproline (PPII) hellx conformation. Two proline residues directly contact the receptor. Other prolines in the ligands appear to function as a molecular scaffold, promoting the formation of the PPII helix.
What does PDZ domain stand for?
PDZ is an initialism combining the first letters of the first three proteins discovered to share the domain — post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1).
What do SH2 domains do?
Abstract. Src homology 2 (SH2) domains are protein modules (of approximately 100 amino acids) found in many proteins involved in tyrosine kinase signalling cascades. Their function is to bind tyrosine-phosphorylated sequences in specific protein targets.
What role do the SH2 and Sh3 domains play in the function of GRB2?
What role do Sh2 and Sh3 domains play in the function of GRB2? GRB2 is an adaptor protein. It contains one Sh2 domain, and two Sh3 domains on the N terminal and C terminal ends. Sh3 directs the binding of proline rich proteins of other compounds, and Sh2 directs the binding of tyrosine phosphorylated sequences.
What do PDZ domains bind to?
PDZ domains bind specific sequence motifs, usually found at the very C-terminus of proteins or, more rarely, at the end of β hairpin structures. PDZ domains bind their ligands, in a manner reminiscent of PTB domains, by incorporating them through hydrogen bonds as an extra strand in a β-sheet.
Is Homer a PDZ domain protein?
PDZ domains are often associated with other protein domains and these combinations allow them to carry out their specific functions. Three of the most well documented PDZ proteins are PSD-95, GRIP, and HOMER.
What is an SH2 domain and what role does it play in signaling pathways?
SH2 domains allow proteins containing those domains to dock to phosphorylated tyrosine residues on other proteins. SH2 domains are commonly found in adaptor proteins that aid in the signal transduction of receptor tyrosine kinase pathways.
Which intracellular proteins contain SH2 domains?
The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src oncoprotein and in many other intracellular signal-transducing proteins. SH2 domains allow proteins containing those domains to dock to phosphorylated tyrosine residues on other proteins.
What is the function of GRB2?
Grb2 is a positive regulator of Ras signaling downstream of many growth factor receptors, and plays an important function in embryogenesis and malignant transformation (15, 16). It contains one central SH2 domain flanked by two SH3 domains. The latter can associate with Sos, a GDP/GTP exchange factor (GEF) for Ras.