In some occasions, you will have to write an essay in the extremely short amount of time on the exam in college or high school. Also, you may be a little bit of a procrastinator, and find yourself in a situation when the paper is due tomorrow morning, and you have not even chosen the topic yet. Even though a last-minute essay cannot look as great as a work prepared successively and carefully within the whole time given, you still have a chance to submit a decent paper. The working process will require your full attention and a lot of effort, even if you are assigned a simple essay. However, if you learn the next few tips, the essay writing will seem significantly easier and feasible even when you are short on time.

Firstly, clean up your working space to get started. Make sure you have everything you need on the table, take a pen, a few sticky notes, your laptop, and read through the assignment requirements. In case no prompt is given, search for good essay topics, and pick a few uncommon and interesting ones you will be able to write about. Making a final choice, think which topic is the most relevant to your current studies and will not take too much to research.

Afterwards, look for the most trustworthy sources or the ones you are certainly allowed to use. If you are not sure, access the online library or any free services where you can look for the books and articles for your essay. Use sticky notes to write down the information and put them in front of you to see how much data has been gathered and if you need to continue researching. Reread these notes from time to time and cross out the info you do not find relevant anymore.

When you have the data you need to produce a quality work, it is crucial to think about the structure of the future paper. If you are not sure how to write an essay outline properly, check what your essay type is first. Each type is organized differently, so you need to look up the structure every time you are given an essay homework. You can also search for an example of the essay on your topic, and adhere to its outline. No matter what kind of essay you are going to write, it is important to start with a thesis statement. It should declare what problem you will review in the paper, and which facts or arguments you will use to do it professionally. As these arguments will be discussed in the main part of the essay, outline the body paragraphs and put down a few sentences with the rough description of each paragraph. Think of the way you will engage the reader in the introduction, and which thought will be conclusive for the paper. When the direction of the work is clear from the outline, use it to draft the first version of the essay.

If you are not used to model essay writing, do not worry - your draft should not necessarily look like a masterpiece. It is only the depiction of your thoughts, and as you will have them written down, it will be easier to create a good essay. There is no best way to write an essay, so trust the working methods you usually use. You may like taking short breaks once in a few minutes, or write everything in one sit - just make sure to keep the focus on writing and avoid the urge to call a friend or watch something online. Thus, you will finish the paper faster, and will not feel guilty for engaging in other activities afterwards.

Do not forget to go through the essay a few times after the completion. Everyone makes typos and mistakes by accident, but it is about you to find and fix them before your teacher does. If you need help with an essay editing, try asking a friend or a family member to read and analyze your work. Also, you can order editing services in case your paper needs to be perfectly polished so that you can submit an ideal essay and get an excellent grade.

As these steps are simple to follow, you will not have any problems coping with an essay on time. Try the whole procedure at least once, and you will not have to use any other tips preparing an essay paper during your studies!

What does UDP Glucuronyl transferase do?

UDP-glucuronosyltransferase (UGT) enzymes catalyze the attachment of a glucuronic acid moiety to various drugs and other xenobiotics, as well as to endogenous compounds such as bilirubin. This conjugation promotes their excretion.

What is the function of Glucuronyl transferase enzyme?

Glucuronyl transferase is a liver enzyme. It changes bilirubin into a form that can be removed from the body through the bile. It also changes some hormones, medicines, and toxins into non-harmful products. The skin can take on a yellow color (jaundice) if the body does not produce enough glucuronyl transferase.

What is UGT pathway?

In humans, the UGT pathway is mediated by 22 enzymes that catalyse the covalent addition of sugars from nucleotide UDP-sugar donors to hydroxyl, carboxyl or amino groups of a diversity of dissimilar endogenous metabolites and toxic exogenous chemicals (Fig. 1).

What does the UGT1A1 gene do?

Normal Function. The UGT1A1 gene belongs to a family of genes that provide instructions for making enzymes called UDP-glucuronosyltransferases. These enzymes perform a chemical reaction called glucuronidation, in which a compound called glucuronic acid is attached (conjugated) to one of a number of different substances …

Which enzyme is responsible for the conjugation of bilirubin?

Bilirubin is conjugated within the hepatocyte to glucuronic acid by a family of enzymes, termed uridine-diphosphoglucuronic glucuronosyltransferase (UDPGT).

What is UDP glucuronyl transferase deficiency?

Deficiency, UDP-glucuronosyltransferase: Underactivity of a liver enzyme that is essential to the disposal of bilirubin (the chemical that results from the normal breakdown of hemoglobin from red blood cells).

What is conjugated vs unconjugated bilirubin?

Bilirubin exists in two forms; unconjugated and conjugated. Unconjugated bilirubin is insoluble in water. This means it can only travel in the bloodstream if bound to albumin and it cannot be directly excreted from the body. In contrast, conjugated bilirubin is water soluble.

What happens conjugated bilirubin?

Conjugated bilirubin is excreted through the bile into the intestine, where it is deconjugated by a mucosal enzyme, β-glucuronidase, and reabsorbed into the enterohepatic circulation before it can be excreted with the stool.

Why is UGT important?

Glucuronidation caused by uridine 5′-diphospho-glucuronosyltransferases (UGT) is an important pathway for drug metabolism in humans and other mammals. The inhibition of UGT, although less often observed than CYP inhibition, is a clinically significant form of drug-drug interactions and may lead to toxicity.

What enzyme converts unconjugated bilirubin?

The microsomal enzyme uridine diphosphate–glucuronyl transferase then conjugates the insoluble unconjugated bilirubin with glucuronic acid to form the water-soluble conjugated forms, bilirubin monoglucuronide (15%) and bilirubin diglucuronide (85%).

How do you know if bilirubin is conjugated or unconjugated?

A urine test positive for bilirubin indicates conjugated hyperbilirubinemia. Conjugated bilirubin is soluble in water; therefore, it can be excreted via urine but not unconjugated bilirubin due to water insolubility.

What is UDP Glucuronyl?

UDP‐glucuronyl transferases (UGTs) are a group of enzymes which catalyze the transfer of UDP‐glucuronyl moieties from UDP‐glucuronic acid into a variety of small lipophilic agents, which can be xenobiotics (drugs, environmental toxicants, carcinogens), as well as endogenous substances (steroids, bile acids, bilirubin.