What is B16 melanoma cells?
B16 melanoma is a murine tumor cell line used for research as a model for human skin cancers. B16 cells are useful models for the study of metastasis and solid tumor formation, and were one of the first effective murine tools for metastasis research.
What is B16 ova?
B16-OVA MO4 cell line is a model for cancer immunotherapy, expressing ovalbumin (OVA) in order to facilitate strong immune responses to tumor antigens.
What is B16-F10?
B16-F10 is a cell line exhibiting a morphology of spindle-shaped and epithelial-like cells that was isolated from skin tissue of a mouse with melanoma. Use these cells in your skin cancer research. Animal cells. Organism. Mus musculus, mouse.
Where are B16 cells derived from?
The mouse B16 cell line was originally isolated from C57BL/6J mouse melanocytes and subsequent in vitro expansion led the isolation of a clonal variant B16-F10 that displayed prominent metastasis properties in vivo.
What is syngeneic mouse model?
What is a syngeneic mouse model? Syngeneic mouse models, also known as Allograft mouse tumor systems, consist of tumor tissues derived from the same genetic background as a given mouse strain. As the syngeneic mice retain intact immune systems, they are particularly relevant for studies of immunotherapies.
What is MC38?
MC38 (Corbett el al., Can Res, 1975) is a murine colon adenocarcinoma cell line from a C57BL/6 mouse. The cells are adherent and have a fibroblast morphology. MC38 cells will form tumors and metastases post implantation into syngeneic C57BL/6 mice or immunocompromised mice.
Are melanomas malignant?
Malignant Lentigo (Melanoma) is a precancerous area on the skin that resembles a freckle. It may be brown or black in color and irregular in shape; it usually occurs on the face.
What are OT 1 cells?
Common Name: OT-1. These mice contain transgenic inserts for mouse Tcra-V2 and Tcrb-V5 genes. The transgenic T cell receptor was designed to recognize ovalbumin peptide residues 257-264 (OVA257-264) in the context of H2Kb (CD8 co-receptor interaction with MHC class I).
What is the difference between allogeneic and syngeneic?
A syngeneic stem cell transplant is a type of allogeneic transplant, meaning it comes from a donor. You can only receive a syngeneic transplant if you have an identical twin or triplet who can donate stem cells.
What is orthotopic model?
Orthotopic models involve the seeding of tumor cell lines into the corresponding tissue in animal models. This strategy allows us to assess tumor development in a relevant environment and evaluate efficacy in a preclinical tumor model that mimics the disease process in humans.
What is MC38 tumor model?
The MC38 murine colon carcinoma model can be employed as a robust preclinical immuno-oncology model. Our data supports the use of this tool in investigating novel treatment combinations with radiation, checkpoint inhibitors, costimulatory molecules, or other novel approaches.
What is MC38 tumor?
Description. MC38 (Corbett el al., Can Res, 1975) is a murine colon adenocarcinoma cell line from a C57BL/6 mouse. The cells are adherent and have a fibroblast morphology. MC38 cells will form tumors and metastases post implantation into syngeneic C57BL/6 mice or immunocompromised mice.