What is isosterism?
[ī′säs·tə‚riz·əm] (physical chemistry) A similarity in the physical properties of ions, compounds, or elements, as a result of electron arrangements that are identical or similar.
What is Isosterism in medicinal chemistry?
Definition of Isosterism. Langmuir (1919): Compounds or groups of atoms having the. same number of atoms and electrons.
What is Isosteres example?
Isosteres are atoms, molecules, or ions of similar size containing the same number of atoms and valence electrons. Example 1. Consider neon, the noble gas at the end of the second row of the periodic table. To the left of it, fluorine has one fewer electron.
What is Isosteric replacement?
Bioisosteres – A bioisostere is a molecule resulting from the exchange of an atom or of a group of atoms with an alternative, broadly similar, atom or group of atoms. The objective of a bioisosteric replacement is to create a new molecule with similar biological properties to the parent compound.
Who introduced Isosterism?
The idea of isosterism goes back to Langmuirf in 1919. At that time the word isosterism was used to describe the similarity of molecules or ions which have the same number of atoms and valence electrons e.g. 02-, F-, Ne.
What is a pharmacophore in drug design?
Pharmacophore is defined as “an ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biologic target and to trigger (or block) its biologic response.” From: Pharmacology and Physiology for Anesthesia (Second Edition), 2019.
What are the types of Bioisostere?
Bioisosteres are classified into the following two types: Classical bioisosteres. Nonclassical bioisosteres.
What is Bioisostere importance in drug design?
Introduction: A bioisostere is a powerful concept for medicinal chemistry. It allows the improvement of the stability; oral absorption; membrane permeability; and absorption, distribution, metabolism and excretion (ADME) of drug candidate, while retaining their biological properties.
What is the difference between isosteres and Bioisosteres?
Classical Isosteres are molecules or ions with similar shape and often electronic properties. Many definitions are available. but the term is usually employed in the context of bioactivity and drug development. Such biologically-active compounds containing an isostere is called a bioisostere.
What is the difference between Isoelectronic and isosteres?
The key difference between isoelectronic and isosteres is that isoelectronic chemical species have similar electronic configurations whereas isosteres are chemical species having similar size, the same number of atoms and valence electrons.
What are Bioisosteric groups?
In medicinal chemistry, bioisosteres are chemical substituents or groups with similar physical or chemical properties which produce broadly similar biological properties to another chemical compound.