What is protamine sulfate used for?
Protamine sulfate is used to reverse the anticoagulant effects of heparin following cardiovascular surgical procedures. Systemic hypotension is not uncommon following administration of this drug.
Why do you give protamine?
Protamine is a medication used to reverse and neutralize the anticoagulant effects of heparin. Protamine is the specific antagonist that neutralizes heparin-induced anticoagulation.
How is protamine sulfate given?
Protamine sulfate should be administered by slow intravenous injection over a period of about 10 minutes. No more than 50mg of protamine sulfate should be given in any one dose.
How does protamine reverse heparin?
Protamine sulfate, a derivative of fish sperm, is commonly used for the reversal of anticoagulation effect of unfractionated heparin (UFH) and low-molecular weight heparin (LMWH)….Dalteparin (Fragmin®)
|Time Since Enoxaparin Dose||Protamine Dose|
|> 8 hours||0.5 mg protamine for every 100 units dalteparin|
What type of drug is protamine?
Protamine is a prescription medicine used to treat the symptoms of Heparin Neutralization and to treat an overdose caused by Dalteparin, Tinzaparin and Enoxaparin. Protamine may be used alone or with other medications. Protamine belongs to a class of drugs called Antidotes, Other.
What does protamine mean?
Definition of protamine : any of various strongly basic proteins of relatively low molecular weight that are rich in arginine and are found associated especially with DNA in place of histone in the sperm cells of various animals (such as fish)
When should I take protamine?
What is antidote for heparin?
Expert opinion: Despite of the low therapeutic index, protamine is the only registered antidote of heparins. The toxicology of protamine depends on a complex interaction of the high molecular weight, a cationic peptide with the surfaces of the vasculature and blood cells.
Is protamine an anticoagulant?
The anticoagulant activity of protamine has been attributed to inhibition of contact-activated and tissue factor–induced coagulation. Taken together, in addition to the well-known hemostatic action of protamine in reversing heparin-induced anticoagulation, excess protamine can potentially enhance bleeding tendency.
Can protamine cause bleeding?
An excess of protamine can contribute to coagulopathy, hence predisposing to bleeding with associated morbidity and mortality.
Is protamine zinc insulin?
Protamine zinc insulin (PZI) is a long-acting insulin that is used in the treatment of diabetes, a relatively common disease seen in middle-aged cats and dogs. Insulin is a hormone produced by the pancreas which helps regulate blood sugar levels. Diabetic patients have high blood sugar levels (hyperglycermia).
What class of drug is protamine?
Protamine belongs to a class of drugs called Antidotes, Other.