What is pyrazole derivative?
Pyrazole derivatives play an important role in antitumor agents because of their good inhibitory activity against BRAF(V600E), EGFR, telomerase, ROS Receptor Tyrosine Kinase and Aurora-A kinase. In addition, pyrazole derivatives also show good antiinflammatory and anti-bacterial activities.
Which drugs contain pyrazole ring?
The standard drugs containing the pyrazole ring [pyrazofurin (anticancer), crizotinib (cytoprotective), celecoxib and lonazolac (anti-inflammatory), difenamizole (analgesic), rimonabant (anti-obesity), sildenafil (vasodilator), and fezolamide (antidepressant)] (Hill and Whelan, 1980; Kameyama et al., 1981; Clemett and …
How do you synthesis pyrazole?
Pyrazole or isoxazole derivatives are prepared by a palladium-catalyzed four-component coupling of a terminal alkyne, hydrazine (hydroxylamine), carbon monoxide under ambient pressure, and an aryl iodide.
What are the applications of the pyrazole and its derivatives?
[3] Many pyrazole derivatives has already found their application as nonsteroidal anti-inflammatory drugs clinically, such as anti-pyrine or phenazone (analgesic and antipyretic), metamizole or dipyrone (analgesic and antipyretic), aminopyrine or aminophenazone (anti-inflammatory, antipyretic, and analgesic).
What is the structure of pyrazole?
C3H4N2Pyrazole / Formula
Is pyrazole aromatic?
Pyrazoles are a class of five-membered heterocycles derived from the parent pyrazole, an aromatic azole with molecular formula C3H4N2 and the structure represented in Figure 1.
What is the use of pyrazole?
Derivatives of pyrazole are used as analgesics, antipyretics, anti-inflammatory (e.g., antipyrine, phenylbutazone, celecoxib), antibacterial, tranquilizers, anti-cancers, and diabetes medication.
What is the aromaticity of pyrazole?
Pyrazole has a five-membered aromatic ring structure containing two vicinal nitrogen atoms, an acidic pyrrole-like nitrogen with a lone pair of electrons involved in aromaticity, a basic sp2-hybridized pyridine-like nitrogen and three carbon atoms (Figure 2) [34], and these combined features must be carefully taken …
What is pyrazole structure?
What are the properties of pyrazole?
Pyrazole is an organic compound with the formula C3H3N2H. It is a heterocycle characterized by a 5-membered ring of three carbon atoms and two adjacent nitrogen atoms….Pyrazole.
| Names | |
|---|---|
| Melting point | 66 to 70 °C (151 to 158 °F; 339 to 343 K) |
| Boiling point | 186 to 188 °C (367 to 370 °F; 459 to 461 K) |
| Basicity (pKb) | 11.5 |
What are pyrazole derivatives?
A Short Review on Pyrazole Derivatives and their Applications. Pyrazole is a heterocyclic organic compound having a 5-membered ring structure with three carbon atoms and two neighbor nitrogen atoms. There are several applications of pyrazole core based organic molecules in various areas including pharmacy and agro-chemical industries.
What is the difference between tetrone derivative and pyrazole derivative?
Tetrone derivative ( 331) is one of the products of decomposition of ( 330) which takes place when this reactive intermediate is generated in situ and then the solution is left at room temperature. Diethyl malonic acid and pyrazole derivative ( 332) are additional products of this decomposition.
What are the applications of pyrazole core based organic molecules?
There are several applications of pyrazole core based organic molecules in various areas including pharmacy and agro-chemical industries. There is an increase in the interest of synthesizing, analyzing different properties, and seeking possible applications of pyrazole derivatives.
Why does pyrazole have a low energy gap?
This significant reduction in the energy gap could be attributed to increasing electrons cloud in the pyrazole ring through the re-hybridization of pyridine-like nitrogen to be pyrrole-like nitrogen by protonation. This approach can be used in order to have lower energy gaps in other organic compounds.