Which cells secrete the renin?
The main source of renin is the juxtaglomerular cells (JGCs), which release renin from storage granules. Besides the renin-angiotensin system (RAS) in the JGCs, there exist local RASs in various tissues.
Do macula densa cells secrete renin?
Macula densa cells in the distal nephron, according to the classic paradigm, are salt sensors that generate paracrine chemical signals in the juxtaglomerular apparatus to control vital kidney functions, including renal blood flow, glomerular filtration, and renin release.
What do macula densa cells secrete?
Macula-densa cells may signal granular cells to inhibit renin release by secreting adenosine and/or ATP across the basolateral membrane in response to increased sodium delivery [96, 101, 102].
What are the JG cells?
Juxtaglomerular cells (JG cells), also known as granular cells are cells in the kidney that synthesize, store, and secrete the enzyme renin. They are specialized smooth muscle cells mainly in the walls of the afferent arterioles (and some in the efferent arterioles) that deliver blood to the glomerulus.
What is secreted by macula densa?
The macula densa, in response to the change in the Na concentration in the distal tubules, signals the juxtaglomerular cells to release renin. Renin is stored in granules and the secretion is stimulated by the β-adrenergic response and cAMP augmentation.
What do JG cells do?
What do juxtaglomerular cells produce?
The juxtaglomerular cells secrete renin, and as specialised smooth muscle cells surrounding the afferent arteriole also have the capacity to affect the perfusion of the glomerulus.
What does the juxtaglomerular cells secrete?
What are juxtaglomerular cells?
What causes the JG cells to release renin?
Juxtaglomerular cells secrete renin in response to a drop in pressure detected by stretch receptors in the vascular walls, or when stimulated by macula densa cells.
What is macula densa cells?
Macula densa cells are renal sensor elements that detect changes in distal tubular fluid composition and transmit signals to the glomerular vascular elements. This tubuloglomerular feedback mechanism plays an important role in regulating glomerular filtration rate and blood flow.
Do JG cells secrete erythropoietin?
Furthermore, from the observation of the chronological change of the JG cell, granularity tended to change in parallel with erythropoietin production. This study gave an indirect evidence of the secretion of erythropoietin by juxtaglomerular cells of the kidney.