Can you have MOG and MS?

MOG antibodies were originally thought to be involved in multiple sclerosis (MS), but subsequent studies found it to be a distinct disease.

Is anti MOG an autoimmune disease?

Anti-MOG syndrome is an autoimmune disorder in which the immune system mistakenly attacks myelin oligodendrocyte glycoprotein (MOG). This protein is located on the surface of myelin, an insulating layer that protects nerve cells and helps facilitate communication between them.

What does a positive MOG antibody mean?

Signs & Symptoms. MOG antibody disease preferentially causes inflammation in the optic nerve, but can also cause inflammation in the spinal cord, brain, and brainstem. Symptoms can include: Loss or blurring of vision in one or both eyes. Loss of color vision.

Is NMO and MOG the same?

Background: Damage to astrocytes by anti-aquaporin-4 antibody (AQP4-Ab), also known as NMO antibody, has been implicated as the cause of neuromyelitis optica. Myelin oligodendrocyte glycoprotein (MOG) is well known as the causative protein of multiple sclerosis (MS).

What antibodies are present in MS?

CSF IgG of MS patients contain mainly IgG1 and IgG3. Both subclasses are potent in the activation of the complement cascade. The potential for demyelination by binding of antibodies against MOG and MBP was shown to be related to the ability to fix complement [73]. 4.

Is MOG disease progressive?

MOG antibody disease manifesting as progressive cognitive deterioration and behavioral changes with primary central nervous system vasculitis. Mult Scler Relat Disord. 2019 May;30:48-50. doi: 10.1016/j.

Is MOG disease a disability?

In MOG antibody demyelination, MOG antibodies attack the myelin oligodendrocyte glycoprotein, causing damage to the myelin sheath. AQP4 antibody NMO is highly likely to cause repeated attacks, which can cause severe disability if it is not treated.

What is MOG optic neuritis?

Myelin Oligodendrocyte Glycoprotein (MOG) Optic Neuritis is an antibody mediated demyelinating disease of the central nervous system (CNS) that is a distinct entity from other demyelinating processes of the CNS such as Multiple Sclerosis (MS) or AQP4-Ab-associated neuromyelitis optica spectrum disorder (NMOSD).

Is MOG part of NMO?

MOG is a glycoprotein localized on the surface of the myelin sheath as well as of the cell body and processes of oligodendrocytes (44, 45). According to the revised 2015 NMOSD diagnostic criteria (46), diseases with or without evidence of AQP4-Abs as well as disorders with MOG-Abs can be assigned to the NMO spectrum.

Is IgG elevated in MS?

About 80 percent of MS patients have higher than normal levels of IgG.

How long can you live with MOG disease?

Patients with neuromyelitis optica (NMO) patients have a 91% to 98% five-year survival rate. Current research indicates that neuromyelitis optica (NMO) patients have a 91% to 98% five-year survival rate.