How do NSAIDs heal ulcers?
NSAID-induced ulcers usually heal once the person stops taking the medication. To help the healing process and relieve symptoms in the meantime, the doctor may recommend taking antacids to neutralize the acid and drugs called H2-blockers or proton-pump inhibitors to decrease the amount of acid the stomach produces.
What is the use of Pirenzepine?
Pirenzepine (Gastrozepin), an M1 selective antagonist, is used in the treatment of peptic ulcers, as it reduces gastric acid secretion and reduces muscle spasm.
What is the use of carbenoxolone?
Carbenoxolone is a hemisuccinate derivative of glycyrrhetinic acid, which is used in the treatment of acid peptic disease.
How do you take Pirenzepine?
The dose is usually 50mg up to three times daily. The maximum dose is 150mg (three tablets) in a day. How should pirenzepine be taken? Pirenzepine is usually taken two to three times a day.
What is the mechanism of action of NSAIDs?
NSAIDs mechanism of action The major mechanism of action of NSAIDs is inhibition of the synthesis of prostaglandin (PG), specifically PGE2, via blocking cyclooxygenase (COX), which is the enzyme that converts arachidonic acid into PG.
How does an NSAID work?
NSAIDs block a specific enzyme called cyclooxygenase (or COX) used by the body to make prostaglandins. By reducing production of prostaglandins, NSAIDs help relieve the discomfort of fever and reduce inflammation and the associated pain.
What is the mechanism of action of Pirenzepine?
Pirenzepine is a muscarinic receptor antagonist and binds to the muscarinic acetylcholine receptor. The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.
What is Vasicoselective?
Vasicoselective drugs. Oxybutynin This recently introduced antimuscarinic has high affinity for receptors in urinary bladder and salivary glands with additional smooth muscle relaxant and local anaesthetic properties.
What are cytoprotective agents?
Class Summary. Cytoprotective agents stimulate mucus production and enhance blood flow throughout the lining of the gastrointestinal tract. These agents also work by forming a coating that protects the ulcerated tissue. Examples of cytoprotective agents include misoprostol and sucralfate.
Is carbenoxolone a steroid?
Pharmacology: The active ingredient present in Herpesan Gel namely Carbenoxolone Sodium is derived from glycyrrhizic acid. Carbenoxolone Sodium is steroidal in structure and steroid-like activity has been demonstrated with regard to both anti-inflammatory and mineralocorticoid activity.
What are the side effects of Pirenzepine?
Pirenzepine is well tolerated by most patients, with a low incidence of typical antimuscarinic effects on the gastrointestinal tract, genitourinary system or heart being reported in clinical studies. However, dry mouth and blurred vision are the more common side effects with clinically effective doses.
How do NSAIDs control pain?