How does VEGF facilitate the growth of a tumour?
This metastatic pattern is dependent on establishing angiogenesis at the newly seeded site [14]. Here VEGF plays an important role by promoting neovascularization and enhancing vascular permeability, thus leading to intraabdominal tumor growth, tumor spread, peritoneal carcinomatosis and ascites formation [15].
How does VEGF cause cancer?
VEGF is the key mediator of angiogenesis in cancer, in which it is up-regulated by oncogene expression, a variety of growth factors and also hypoxia. Angiogenesis is essential for cancer development and growth: before a tumor can grow beyond 1-2 mm, it requires blood vessels for nutrients and oxygen.
What is the role of VEGF and bFGF in cell metastasis?
Basic fibroblast growth factor (bFGF) is a secreted multifunctional cytokine and potent stimulator of angiogenesis [5,6]. Vascular endothelial growth factor (VEGF) also plays an important role in inducing endothelial cell proliferation and neovascularization [7,8].
What is the role of VEGF in cancer growth and progression?
The function of vascular endothelial growth factor (VEGF) in cancer is not limited to angiogenesis and vascular permeability. VEGF-mediated signalling occurs in tumour cells, and this signalling contributes to key aspects of tumorigenesis, including the function of cancer stem cells and tumour initiation.
How does VEGF promote angiogenesis?
VEGF promotes tumor angiogenesis through several mechanisms, including enhanced endothelial cell proliferation and survival; increased migration and invasion of endothelial cells; increased permeability of existing vessels, forming a lattice network for endothelial cell migration; and enhanced chemotaxis and homing of …
What is the role of VEGF?
VEGF’s normal function is to create new blood vessels during embryonic development, new blood vessels after injury, muscle following exercise, and new vessels (collateral circulation) to bypass blocked vessels.
Do Tumour cells release VEGF?
VEGF is produced by many cell types including tumor cells,2,3 macrophages,4 platelets,5 keratinocytes,6 and renal mesangial cells. The activities of VEGF are not limited to the vascular system; VEGF plays a role in normal physiological functions such as bone formation,8 hematopoiesis,9 wound healing,10 and development.
How might angiogenesis play a role in cancer metastasis?
The resulting new blood vessels “feed” growing tumors with oxygen and nutrients, allowing the tumor to enlarge and the cancer cells to invade nearby tissue, to move throughout the body, and to form new colonies of cancer cells, called metastases.
What is the function of VEGF?
Vascular endothelial growth factor (VEGF) is considered the master regulator of angiogenesis during growth and development, as well as in disease states such as cancer, diabetes, and macular degeneration.
What does VEGF do to cells?
Vascular endothelial growth factor (VEGF) is an angiogenic factor that regulates angiogenesis by inducing proliferation, migration and permeability of endothelial cells.
Do Tumours secrete VEGF?
VEGF can be secreted as well by tumor cells through the autocrine pathway and can stimulate the function of cancer stemness.