Is tamoxifen citrate an estrogen blocker?

Tamoxifen citrate is another oral SERM that was approved in the 1970s for the treatment of breast cancer. It has tissue specific action and acts as an estrogen receptor blocker in breast tissue and exhibits agonistic properties in the bone and uterus.

Does tamoxifen increase estrogen?

Tamoxifen may increase plasma estrogen concentrations by interfering with normal negative pituitary feedback mechanisms, with a resulting increase in follicle-stimulating hormone-driven ovarian steroidogenesis (12).

Does tamoxifen lower estrogen levels?

Tamoxifen blocks estrogen from connecting to the cancer cells and telling them to grow and divide. While tamoxifen acts like an anti-estrogen in breast cells, it acts like an estrogen in other tissues, like the uterus and the bones. Because of this, it is called a selective estrogen receptor modulator (SERM).

What does tamoxifen citrate do?

A drug used to treat certain types of breast cancer in women and men, to prevent invasive breast cancer in women who have had ductal carcinoma in situ (abnormal cells in the ducts of the breast), and to prevent breast cancer in women who are at a high risk of developing the disease.

What does estrogen blocker do for females?

What do estrogen blockers do for females? Estrogen blockers are chemicals that essentially prevent cancer cells in females from getting the hormones they need to grow, like estrogen. Many breast cancers are sensitive to hormones like estrogen and respond to this type of treatment.

Does tamoxifen cause weight gain?

Tamoxifen (Nolvadex, Soltamox) is the most widely prescribed breast cancer therapy in the world. Some even call it the “backbone” of breast cancer treatment. Even with all that fanfare, tamoxifen has been loosely associated with weight gain. Studies have tracked weight gain and other side effects of the drug for years.

Does tamoxifen lower testosterone?

Context: Tamoxifen, a selective estrogen receptor modulator, suppresses GH secretion in women but not in men. It increases testosterone levels in men. As GH and testosterone stimulate fat metabolism, the metabolic consequences of tamoxifen may be greater in women than in men.

What are the side effects of stopping tamoxifen?

Serious side effects

• Changes in the lining (endometrium) of your uterus. These changes may mean serious problems are starting, including cancer of the uterus.
• Blood clots in your veins or lungs. These can occur for up to 2–3 months after you stop taking tamoxifen.
• Stroke. Symptoms can include:
• Cataracts.
• Liver problems.