What are the long-term effects of ephedrine?
The results showed that long-term exposure to ephedrine had potential neurotoxic effects. Withdrawal after 8 weeks of ephedrine exposure leads to neurotoxicity, neurobehavioral disorders and accompanied by up-regulation of CRF in the prefrontal cortex and hippocampus in rhesus macaques.
Can you take ephedrine long-term?
We conclude that the ephedrine/caffeine combination is safe and effective in long-term treatment in improving and maintaining weight loss. The side-effects are minor and transient and no clinically relevant withdrawal symptoms have been observed.
Is ephedrine hard on the liver?
The severity of liver injury due to ephedrine ranges from mild, asymptomatic elevations in serum enzymes to clinically apparent acute liver injury and to acute liver failure.
What does ephedrine do to the brain?
It activates pathways in the human brain that are responsible for weight loss, but it also activates pathways that could lead to dramatic change in heart rate or blood pressure. Moreover, ephedrine, like nicotine, produces a “high” and can be addictive.
How long can you use ephedrine?
Onset with intravenous use is fast, while injection into a muscle can take 20 minutes, and by mouth can take an hour for effect. When given by injection it lasts about an hour and when taken by mouth it can last up to four hours….Ephedrine.
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Can ephedrine cause heart damage?
Conclusions: It is well documented that ephedra, through its sympathomimetic effects, can cause a range of cardiovascular toxicities including myocarditis, arrhythmias, myocardial infarction, cardiac arrest, and sudden death.
Does ephedrine cause heart damage?
How long does ephedrine stay in your system?
Ephedrine/pseudoephedrine can be detected for up to five days. Some over-the-counter and prescription medications may test positive for amphetamines. False positives are also possible among those taking antihistamines, nasal inhalers, cold medicines, and some pharmaceuticals intended to treat depression.
Does ephedrine affect serotonin?
Ephedrine, which has been used as a decongestant and weight loss agent, causes both central serotonin and dopamine (DA) release (Bowyer et al., 2000).
Does ephedrine cause anxiety?
Data from 50 trials did show, however, that ephedra and ephedrine are associated with 2- to 3-fold increases in psychiatric symptoms (such as irritability and anxiety), autonomic symptoms (jitteriness, trouble sleeping), upset stomach, and heart palpitations.