What causes Pseudolymphoma?
Pseudolymphoma, also called as cutaneous lymphoid hyperplasia, is a skin lesion having lymphomatous appearance mimicking lymphoma that results from known or unknown stimulus like insect bites, vaccination, trauma, folliculitis, drugs, jewelry, and contactants.
What does Pseudolymphoma look like?
Pseudolymphomatous drug eruption due to captopril, marked by erythematous to purple papules, patches, and plaques. This erythrodermic pseudolymphoma (T-cell pattern) typifies drug-induced pseudolymphoma, which is most often secondary to anticonvulsant therapy.
What drugs cause Pseudolymphoma?
Anticonvulsants, typically phenytoin and carbamazepine, are the most frequent cause of drug-induced pseudolymphoma.
Can Pseudolymphoma turn into lymphoma?
Although rare, reports of cutaneous B-cell pseudolymphoma evolving into B-cell lymphoma have been described. In one study of 4 cases, transformation of 1 case of pseudolymphoma into a large B-cell lymphoma was identified, similar to our patient [7].
Is pseudolymphoma curable?
Cases of cutaneous pseudolymphoma documented to occur as a result of infection should be appropriately treated. In idiopathic cases of cutaneous pseudolymphoma, treatment is not mandatory. Cures may be effected via surgical removal, cryosurgery, or local irradiation.
What is skin lymphoma?
Lymphoma is a cancer that starts in cells that are part of the body’s immune system. Rare lymphomas that start in the skin are called skin lymphomas (or cutaneous lymphomas). If you have a skin lymphoma or are close to someone who does, knowing what to expect can help you cope.
Is mycosis fungoides caused by a fungal infection?
The name mycosis fungoides is very misleading—it loosely means “mushroom-like fungal disease”. The disease, however, is not a fungal infection but rather a type of non-Hodgkin’s lymphoma. It was so named because Alibert described the skin tumors of a severe case as having a mushroom-like appearance.
Is Pseudolymphoma curable?
How do you treat a Pseudolymphomatous allergic reaction?
Treatment modalities include topical and intralesional application of glucocorticosteroids as well as surgical excision and laser therapy [7, 9-13]. Additionally, systemic therapy with hydroxychloroquine was effective in a case of tattoo-associated pseudolymphomatous reaction in the green part of the tattoo [8].
How is pseudolymphoma treated?
In idiopathic cases of cutaneous pseudolymphoma, treatment is not mandatory. Cures may be effected via surgical removal, cryosurgery, or local irradiation. Some reports have noted a response to topical or injected corticosteroids and topical immunomodulators such as tacrolimus.
Who gets skin lymphoma?
In general, skin lymphomas are slightly more common in men than women. They are usually diagnosed in older people, most often those aged between 50 and 74. Only about 1 in 5 skin lymphomas affect people under 50. Very rarely, some types of skin lymphoma can develop in children.
What are the histologic characteristics of lymphocytoma cutis?
There are no agreed histologic criteria; however, features that suggest lymphocytoma cutis include well-formed, non-expanded, reactive germinal centers, the majority of the infiltrate consisting of small round lymphocytes with a B:T cell ratio of <3 : 1 and polytypic expression of kappa and lambda light chains.
What is borrelial lymphocytoma cutis?
Lymphocytoma cutis (LC) is one of the most common types of cutaneous B cell pseudolymphoma. Borrelial LC occurs most commonly in areas endemic for Ixodes ricinustick in Europe, and it is rare in North America.
What are the treatment options for lymphocytoma cutis?
There is no therapy of proven value for lymphocytoma cutis, with only anecdotal case reports and small series reported and no clinical trials in the literature. If a cause can be identified, the causative agent should be removed.
What causes lymphocytoma cutis (cutaneous lymphoid hyperplasia)?
Lymphocytoma cutis (cutaneous lymphoid hyperplasia, cutaneous B-cell pseudolymphoma, Spiegler–Fendt sarcoid) is an entity encompassing a spectrum of benign B-cell lymphoproliferative diseases that share clinical and histopathologic features. Various stimuli can induce lymphocytoma cutis, but in most cases the cause is not known.