What chemicals can cause basal cell carcinoma?
Exposure to certain chemicals Workers exposed to coal tar, paraffin, and certain types of petroleum products may also have an increased risk of skin cancer.
How is Gorlin syndrome diagnosed?
Genetic testing
- An exam of the patient’s skin for basal cell carcinomas, pitting on hands and feet, areas of skin discoloration, and small cysts (milia) around the eyes and nose and elsewhere.
- An exam of the face and head to identify any abnormalities of the face, skull, teeth and jaws.
What is a major contributor to the risk of developing basal cell carcinoma?
Exposure to ultraviolet (UV) radiation from the sun and indoor tanning is the major cause of BCCs and most skin cancers.
What is the most common cause of basal cell carcinoma?
Most basal cell and squamous cell skin cancers are caused by repeated and unprotected skin exposure to ultraviolet (UV) rays from sunlight, as well as from man-made sources such as tanning beds.
Can chemicals cause melanoma?
Chemical exposure: Certain chemicals, including arsenic, industrial tar, coal, paraffin and certain types of oil, may increase the risk for certain types of non-melanoma skin cancers.
What is Goltz Gorlin syndrome?
Gorlin-Goltz syndrome is an autosomal dominant inherited disorder characterized by the presence of multiple odontogenic keratocysts along with various cutaneous, dental, osseous, ophthalmic, neurological, and sex organ abnormalities.
What causes basal cell nevus?
Basal cell nevus syndrome is caused by changes in a tumor suppressor gene, called PTCH1. This gene is located on chromosome 9. Mutations in this gene may increase the risk of some cancers. Molecular genetic testing of PTCH1 is available on a clinical basis.
How does sunlight contribute to the development of melanoma?
Acquired gene mutations For example, ultraviolet (UV) rays are clearly a major cause of melanoma. UV rays can damage the DNA in skin cells. Sometimes this damage affects certain genes that control how the cells grow and divide. If these genes no longer work properly, the affected cells may become cancer cells.
How is basal cell caused?
Most basal cell and squamous cell skin cancers are caused by repeated and unprotected skin exposure to ultraviolet (UV) rays from sunlight, as well as from man-made sources such as tanning beds. UV rays can damage the DNA inside skin cells.