What does CK7 positive and CK20 positive mean?
For example, a CK7-negative/CK20-positive phenotype is often associated with carcinomas of colorectal origin, whereas a CK7-positive/CK20-negative phenotype is seen in a wide variety of carcinomas, including carcinomas of the lung, breast, thyroid, pancreas, and female genital tract.
What are CK7 and CK20?
Among the most useful cytokeratins are CK7 and CK20 [7]. CK7 is found in many ductal and glandular epithelia, including lung, breast, ovary, and endometrium [8, 9]. CK20 is expressed in the gastrointestinal (GI) epithelium, urothelium, and Merkel cells [10].
Is CK7 positive cancer?
Tumors with positivity > 10% and > 25% of tumor cells were considered CK7 and CK20 positive, respectively.
What is CDX2 and CK20?
CDX2 is a sensitive marker for rectal origin of adenocarcinoma. It can be helpful in cases with metastatic rectal carcinoma, especially those with CK7+/CK20+ or CK20-/CK7- immunophenotype. In this study, CDX2 expression was not influenced by the grade (differentiation) of rectal adenocarcinoma.
What does it mean when a tumor is positive for CK7?
What does positive for CK7 mean? Positive for CK7 means that immunohistochemistry was performed and CK7 protein was seen inside the cells of interest in the tissue sample. Reactive is another term that pathologists use to describe cells that are producing CK7.
What does CDX2 positive mean?
These results suggest that positive CDX2 staining represents a highly sensitive and specific marker of metastatic colorectal carcinoma in both biopsy and resected specimens, and is superior to staining for the CK7-/20+ phenotype.
What does positive for CDX2 mean?
What is CDX2 in cancer?
CDX2 is a homeobox protein responsible for the maintenance of the intestinal phenotype [1, 2]. Over the last decade, CDX2 has been linked to colorectal cancer (CRC) progression, with reduced expression of the protein associated with more advanced tumor stage, vessel invasion, and metastasis [3–7].
What does CDX2 stand for?
Caudal-type homeobox 2 (CDX2) is an intestine-specific transcription factor with potential prognostic and predictive effect, but the importance in mCRC has not been fully investigated.
Where is CDX2 found?
The CDX2 protein is a homeobox transcription factor expressed in the nuclei of intestinal epithelial cells, playing an essential role in the development and function of the digestive system.
What CK20 positive?
Positive for CK20 means that the CK20 protein was seen inside the cells of interest in the tissue sample. Reactive is another term that pathologists use to describe cells that are producing CK20.