What is leukocyte depletion?

A leucocyte depletion process is uncontrolled if a control chart or equivalent is not in operation for the process or if a current control chart or equivalent displays control limit or trend warnings.

What is the purpose of leukoreduction?

Leukoreduction: A process used to filter and remove white blood cells from whole blood before transfusion. The reason why white blood cells (leukocytes) are removed from blood is because they provide no benefit to the recipient but can carry bacteria and viruses to the recipient.

What is meant by Alloimmunization?

Alloimmunization is an immune response to foreign blood types (antigens). Because the red blood cells of different individuals express many different blood group antigens, exposure to foreign red blood cells, such as in cases of transfusion or pregnancy, can lead to the formation of antibodies.

What are Leukoreduced platelets?

Leukoreduction involves the removal of WBCs from cellular components to reduce the risk of HLA alloimmunization, CMV transmission, and febrile nonhemolytic transfusion reactions.

What is SAG M?

SAGM consists of saline, adenine, a sugar (glucose) and mannitol, a free radical scavenger and membrane stabilizer, and thus provides nutrients for longer storage and better flow [12, 34]. The in vivo survival rate for recipients treated with SAGM blood units was found to be 73% at 24 h after transfusion. …

Why are blood products Leukoreduced and irradiated?

Irradiated Blood: Irradiation is needed to destroy all nucleated cells and living leukocytes (white blood cells), particularly lymphocytes that could cause transfusion associated graft versus host disease (TAGVD).

Why is blood leukocyte reduced?

There are three well-accepted reasons to leukocyte-reduce blood products: Prevention of alloimmunization to foreign HLA antigens. Prevention of febrile nonhemolytic transfusion reactions. Prevention of CMV transmission (though this one is admittedly still debated)

Why are white blood cells removed before transfusion?

Leukoreduction is a process in which the white blood cells are intentionally removed from donated blood in order to reduce the risk of adverse reactions in people receiving the blood transfusion.

What causes alloimmunization?

Introduction: Alloimmunization is caused by exposure to erythrocytes from a donor that expresses blood group antigens other than those of the recipient and is related to processes that alter the balance of the immune system.

What is platelet alloimmunization?

Refractoriness to platelet transfusions HLA alloimmunization is the most common cause of platelet refractoriness. The immune response to non-HLA antigens, present on the platelet surface (most importantly, platelet-specific antigens or HPAs) are involved less commonly.

Who needs Leukoreduced blood?

Generally accepted indications for leukoreduction of blood products include: (1) reduction of HLA alloimmunization risk in patients who require long term platelet support, or for potential organ transplant recipients; (2) reduction of CMV transmission in at-risk patients; and (3) reduction of the rate of recurrent …

Is FFP Leukoreduced?

Twenty units of FFP were filtered through standard leukoreduction red blood cell filters (Sepacell 500; Baxter, Deerfield, IL). There were no FFP-specific leukoreduction filters available in our blood bank. Leukoreduction was performed at room temperature without any priming of the filter.