What is Sca-1 a marker for?
Sca-1, a member of the Ly-6 family of glycosylphosphatidylinositol-linked proteins, has been used as a marker to enrich for hematopoietic and mammary gland stem cells (18, 19).
Which cells Express Sca-1?
Cardiac progenitor cells (CPCs), which express Sca-1, are also found in human adult myocardium and the cells can divide and expand after myocardial infarction (Beltrami et al., 2001, 2003; Oh et al., 2003; Müller et al., 2005).
What is SCA1+?
Stem cell antigen-1 (Sca-1) is a glycosyl-phosphatidylinositol-anchored membrane protein that is expressed in a sub-population of muscle stem and progenitor cell types. Reportedly, Sca-1 regulates the myogenic property of myoblasts and Sca-1-/- mice exhibited defective muscle regeneration.
What is CD34 marker?
CD34 is predominantly regarded as a marker of hematopoietic stem cells (HSC) and hematopoietic progenitor cells. However, CD34 is now also established as a marker of several other nonhematopoietic cell types, including vascular endothelial progenitors 1 and embryonic fibroblasts 2.
Is SCA hereditary?
SCA is hereditary, progressive, degenerative, and often fatal. There is no known effective treatment or cure. SCA can affect anyone of any age. The disease is caused by either a recessive or dominant gene.
What is SCA in biology?
Spinocerebellar ataxia (SCA) is a term referring to a group of hereditary ataxias that are characterized by degenerative changes in the part of the brain related to the movement control (cerebellum), and sometimes in the spinal cord.
What are LSK cells?
KSL cells in cell biology are an early form of mouse/murine hematopoietic stem cells. Characteristics are Kit (+), Sca-1 (+) and Lin (-). HSCs [Hematopoietic stem cells] in murine cultures show phenotypic markers as being CD34-, CD150+, and Flt3- for LTR [long-term reconstitution].
What is CD45 a marker for?
CD45 is used as a marker of all hematopoietic cells (blood cells), except for mature erythrocytes (red blood cells) and platelets.
What is CD34-positive mean?
In normal conditions, CD34-positive cells account for about 1–2% of the total bone marrow cells. The TdT+ subset of precursor B cells (hematogones) is also positive for CD34. Approximately 40% of AMLs and over 50% of ALLs express CD34. CD34 is also expressed in a garden variety of nonhematopoietic tumors.
Can SCA be cured?
There is currently no treatment or cure to slow or stop the progression of SCA or the damage to the cerebellum. Patients work closely with a neurologist to develop a personal plan to deal with the symptoms of ataxia, which can include speech therapy, occupational therapy, and physical therapy.
Is SCA an autoimmune disease?
SCA is hereditary, progressive, degenerative, and often fatal. There is no known effective treatment or cure. SCA can affect anyone of any age. The disease is caused by either a recessive or dominant gene….
How do you diagnose SCA?
Genetic testing is the best way to confirm SCA and identify the specific type, especially when a person also has family members with similar features. However, this is only an option if the disease-causing gene for that particular type of SCA has been identified.