What is the drug rabeprazole sodium used for?
Rabeprazole is used to treat duodenal ulcers, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome, a condition where the stomach produces too much acid. It may also be used together with antibiotics (eg, amoxicillin, clarithromycin) to treat ulcers associated with infections caused by the H.
What class of drug is rabeprazole?
Rabeprazole is in a class of medications called proton-pump inhibitors. It works by decreasing the amount of acid made in the stomach.
What are the characteristics of rabeprazole?
Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug – in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.
Is rabeprazole safe for kidneys?
Rabeprazole can cause kidney problems. Tell your doctor if you are urinating less than usual, or if you have blood in your urine. Diarrhea may be a sign of a new infection. Call your doctor if you have diarrhea that is watery or has blood in it.
Does rabeprazole increase blood sugar?
In OGTTs, rabeprazole decreased the values of AUCinsulin and the maximum insulin concentration. Although rabeprazole showed inhibition effect on OCT2-mediated metformin transport, the glucose-lowering effect of metformin remained the same regardless of its PK changes.
What is the mechanism of action of rabeprazole?
Mechanism Of Action Rabeprazole blocks the final step of gastric acid secretion. In gastric parietal cells, rabeprazole is protonated, accumulates, and is transformed to an active sulfenamide. When studied in vitro, rabeprazole is chemically activated at pH 1.2 with a half-life of 78 seconds.
What is another name for rabeprazole sodium?
Aciphex (rabeprazole sodium) is a proton pump inhibitor (PPI) to reduce stomach acid and is used for the treatment of gastroesophageal reflux disease (GERD), duodenal ulcers, and used in combination with antibiotics to treat Helicobacter pylori (H. pylori) bacterial infections in the stomach.
What are the contraindications of rabeprazole?
Who should not take RABEPRAZOLE SODIUM?
- diarrhea from an infection with Clostridium difficile bacteria.
- inadequate vitamin B12.
- low amount of magnesium in the blood.
- low amount of calcium in the blood.
- liver problems.
- a type of kidney inflammation called interstitial nephritis.
- subacute cutaneous lupus erythematosus.
Can rabeprazole affect kidneys?
Can rabeprazole cause liver problems?
Rabeprazole therapy is associated with a low rate of transient and asymptomatic serum aminotransferase elevations and is a rare cause of clinically apparent liver injury.
Can PPI increase creatinine levels?
Patients treated with PPI also had a significantly elevated risk of doubling of serum creatinine level (HR, 1.53; 95% CI, 1.42 to 1.65), of eGFR decline >30% (HR, 1.32; 95% CI, 1.28 to 1.37), and of ESRD (HR, 1.96; 95% CI, 1.21 to 3.18).
What do you need to know about rabeprazole?
Rabeprazole 1 Rabeprazole is a proton pump inhibitor that decreases the amount… 2 Important Information. Rabeprazole can cause kidney problems. 3 Before taking this medicine. Heartburn can mimic early symptoms of a heart attack. 4 Rabeprazole is usually taken once per day.
What is the generic name for rabeprazole 10 mg?
Rabeprazole Generic name: rabeprazole (ra BEP ra zole) Brand name: AcipHex, AcipHex Sprinkle Dosage forms: oral delayed release capsule (10 mg; 5 mg); oral delayed release tablet (20 mg)
Is rabeprazole a pyridine?
Rabeprazole is a member of benzimidazoles, a sulfoxide and a member of pyridines. It has a role as an EC 3.6.3.10 (H (+)/K (+)-exchanging ATPase) inhibitor and an anti-ulcer drug. It is a conjugate acid of a rabeprazole (1-).
How long does it take for rabeprazole sodium to work?
Available as rabeprazole sodium; dosage expressed in terms of the salt. Adolescents ≥12 years of age: 20 mg once daily for up to 8 weeks. 20 mg once daily for 4 weeks; may give additional 4 weeks if symptoms are not completely resolved. 20 mg once daily for 4–8 weeks.