What is the side effect of daunorubicin?
Common side effects of Cerubidine include: nausea, vomiting, constipation, diarrhea, and loss of appetite. Cerubidine may cause urine to turn a reddish color. This is a normal, harmless effect of Cerubidine and should not be mistaken for blood in the urine.
What metabolite does daunorubicin target?
Daunorubicin has been determined to have a terminal half-life of 18.5 h (+/- 4.9). Daunorubicinol, the primary active metabolite has been determined to have a terminal half-life of 26.7 h (+/- 12.8).
Does daunorubicin cause bone marrow suppression?
A liposomal formulation of daunorubicin is available as a first line therapy for advanced HIV related Kaposi sarcoma. Common side effects of daunorubicin include bone marrow suppression, nausea, vomiting, mucositis, diarrhea, alopecia, skin rash, red urine and fever.
What is the mechanism of action of daunorubicin?
MECHANISM OF ACTION: Daunorubicin is an anthracycline antibiotic which damages DNA by intercalating between base pairs resulting in uncoiling of the helix, ultimately inhibiting DNA synthesis and DNA-dependent RNA synthesis.
What is the antidote for daunorubicin?
3.3. 2 Antidotes and Treatments for Extravasation
| Compress Required | |
|---|---|
| Dactinomycin DAUNOmycin (DAUNOrubicin) DOXOrubicin Epirubicin Mitoxantrone | COLD |
| VinBLAStine VinCRIStine Vinorelbine | WARM |
What is the difference between DOXOrubicin and daunorubicin?
Daunorubicin reached higher intracellular peak concentrations than doxorubicin, but the latter drug was retained much longer. The cell/plasma concentration ratio was higher for daunorubicin than for its reduced metabolite daunorubicinol. No doxorubicinol was found intracellularly.
Is daunorubicin a Vesicant?
Daunorubicin is a vesicant. A vesicant is a chemical that causes extensive tissue damage and blistering if it escapes from the vein. The nurse or doctor who gives this drug must be carefully trained.
What drug is used for extravasation?
Dexrazoxane has the most evidence to support its use in human medicine. In two single arm trials among 54 human patients with anthracycline extravasations, dexrazoxane was shown to be effective in preventing severe tissue damage.
What is daunorubicin doxorubicin?
Daunorubicin and doxorubicin, two antibiotics belonging to the anthracycline group, are widely used in human cancer chemotherapy. Their activity has been attributed mainly to their intercalation between the base pairs of native DNA.