In some occasions, you will have to write an essay in the extremely short amount of time on the exam in college or high school. Also, you may be a little bit of a procrastinator, and find yourself in a situation when the paper is due tomorrow morning, and you have not even chosen the topic yet. Even though a last-minute essay cannot look as great as a work prepared successively and carefully within the whole time given, you still have a chance to submit a decent paper. The working process will require your full attention and a lot of effort, even if you are assigned a simple essay. However, if you learn the next few tips, the essay writing will seem significantly easier and feasible even when you are short on time.

Firstly, clean up your working space to get started. Make sure you have everything you need on the table, take a pen, a few sticky notes, your laptop, and read through the assignment requirements. In case no prompt is given, search for good essay topics, and pick a few uncommon and interesting ones you will be able to write about. Making a final choice, think which topic is the most relevant to your current studies and will not take too much to research.

Afterwards, look for the most trustworthy sources or the ones you are certainly allowed to use. If you are not sure, access the online library or any free services where you can look for the books and articles for your essay. Use sticky notes to write down the information and put them in front of you to see how much data has been gathered and if you need to continue researching. Reread these notes from time to time and cross out the info you do not find relevant anymore.

When you have the data you need to produce a quality work, it is crucial to think about the structure of the future paper. If you are not sure how to write an essay outline properly, check what your essay type is first. Each type is organized differently, so you need to look up the structure every time you are given an essay homework. You can also search for an example of the essay on your topic, and adhere to its outline. No matter what kind of essay you are going to write, it is important to start with a thesis statement. It should declare what problem you will review in the paper, and which facts or arguments you will use to do it professionally. As these arguments will be discussed in the main part of the essay, outline the body paragraphs and put down a few sentences with the rough description of each paragraph. Think of the way you will engage the reader in the introduction, and which thought will be conclusive for the paper. When the direction of the work is clear from the outline, use it to draft the first version of the essay.

If you are not used to model essay writing, do not worry - your draft should not necessarily look like a masterpiece. It is only the depiction of your thoughts, and as you will have them written down, it will be easier to create a good essay. There is no best way to write an essay, so trust the working methods you usually use. You may like taking short breaks once in a few minutes, or write everything in one sit - just make sure to keep the focus on writing and avoid the urge to call a friend or watch something online. Thus, you will finish the paper faster, and will not feel guilty for engaging in other activities afterwards.

Do not forget to go through the essay a few times after the completion. Everyone makes typos and mistakes by accident, but it is about you to find and fix them before your teacher does. If you need help with an essay editing, try asking a friend or a family member to read and analyze your work. Also, you can order editing services in case your paper needs to be perfectly polished so that you can submit an ideal essay and get an excellent grade.

As these steps are simple to follow, you will not have any problems coping with an essay on time. Try the whole procedure at least once, and you will not have to use any other tips preparing an essay paper during your studies!

What is TLR antagonist?

TLR agonists have been developed to treat allergies, cancers, and chronic infections by upregulating the innate immune system. TLR antagonists may be used to treat a number of inflammatory conditions, such as rheumatoid arthritis and systemic lupus erythematosus.

What is a Toll-like receptor agonist?

Toll-like receptor (TLR) agonists represent a novel approach for stimulating an effective antitumor immune response in patients with CTCL through augmentation of either dendritic cells or T-cell effects.

What does TLR9 bind?

TLR9 is known to bind to CpG DNA, and here, we identified another DNA binding site in TLR9 that binds DNA containing cytosine at the second position from the 5′ end (5′-xCx DNA). 5′-xCx DNAs bound to TLR9 in the presence of CpG DNA and cooperatively promoted dimerization and activation of TLR9.

Which are toll-like receptors?

Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single-pass membrane-spanning receptors usually expressed on sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes.

Is LPS a TLR agonist?

On the contrary, in mouse primary microglia cultures, it was observed that RS-LPS can develop TLR-4 agonistic properties inducing the release of cytokines and chemokines [27].

What does a TLR target?

Toll-like receptors (TLRs) are an important family of receptors that constitute the first line of defense system against microbes. They can recognize both invading pathogens and endogenous danger molecules released from dying cells and damaged tissues and play a key role in linking innate and adaptive immunity.

How do Toll-like receptors work?

Toll-like receptors (TLRs) are a class of pattern recognition receptors (PRRs) that initiate the innate immune response by sensing conserved molecular patterns for early immune recognition of a pathogen (1).

Which of the following is Recognised as TLR9?

TLR9 was first identified by its ability to recognize unmethylated 2′-deoxyribo(cytidine-phosphate-guanosine) (CpG) DNA from bacteria, and viral DNA is also recognized by TLR9 (Bauer et al., 2001; Hemmi et al., 2000; Hochrein et al., 2004; Tabeta et al., 2004).

How does TLR9 bind to DNA?

A recent structural study confirmed that TLR9 has a second DNA-binding site that binds to DNA containing cytosine at the second position from the 5′ end (5′-xCx DNA), which cooperatively promotes the dimerization and activation of TLR9 (Ohto et al., 2018).

What is Toll-like receptors and what is their functions?

What are TLR ligands?

Endogenous TLR ligands are a group of molecules derived from host tissues or cells, either components of cells or induced gene products in specific conditions.

What is TLR4 antagonist?

The TLR4 antagonist ibudilast (AV411) is being studied in advanced clinical trials for the treatment of chronic pain and addiction withdrawal84. Ibudilast suppresses pro-inflammatory cytokines such as TNF-α and IL-6, and may induce the anti-inflammatory cytokine IL-10.