In some occasions, you will have to write an essay in the extremely short amount of time on the exam in college or high school. Also, you may be a little bit of a procrastinator, and find yourself in a situation when the paper is due tomorrow morning, and you have not even chosen the topic yet. Even though a last-minute essay cannot look as great as a work prepared successively and carefully within the whole time given, you still have a chance to submit a decent paper. The working process will require your full attention and a lot of effort, even if you are assigned a simple essay. However, if you learn the next few tips, the essay writing will seem significantly easier and feasible even when you are short on time.

Firstly, clean up your working space to get started. Make sure you have everything you need on the table, take a pen, a few sticky notes, your laptop, and read through the assignment requirements. In case no prompt is given, search for good essay topics, and pick a few uncommon and interesting ones you will be able to write about. Making a final choice, think which topic is the most relevant to your current studies and will not take too much to research.

Afterwards, look for the most trustworthy sources or the ones you are certainly allowed to use. If you are not sure, access the online library or any free services where you can look for the books and articles for your essay. Use sticky notes to write down the information and put them in front of you to see how much data has been gathered and if you need to continue researching. Reread these notes from time to time and cross out the info you do not find relevant anymore.

When you have the data you need to produce a quality work, it is crucial to think about the structure of the future paper. If you are not sure how to write an essay outline properly, check what your essay type is first. Each type is organized differently, so you need to look up the structure every time you are given an essay homework. You can also search for an example of the essay on your topic, and adhere to its outline. No matter what kind of essay you are going to write, it is important to start with a thesis statement. It should declare what problem you will review in the paper, and which facts or arguments you will use to do it professionally. As these arguments will be discussed in the main part of the essay, outline the body paragraphs and put down a few sentences with the rough description of each paragraph. Think of the way you will engage the reader in the introduction, and which thought will be conclusive for the paper. When the direction of the work is clear from the outline, use it to draft the first version of the essay.

If you are not used to model essay writing, do not worry - your draft should not necessarily look like a masterpiece. It is only the depiction of your thoughts, and as you will have them written down, it will be easier to create a good essay. There is no best way to write an essay, so trust the working methods you usually use. You may like taking short breaks once in a few minutes, or write everything in one sit - just make sure to keep the focus on writing and avoid the urge to call a friend or watch something online. Thus, you will finish the paper faster, and will not feel guilty for engaging in other activities afterwards.

Do not forget to go through the essay a few times after the completion. Everyone makes typos and mistakes by accident, but it is about you to find and fix them before your teacher does. If you need help with an essay editing, try asking a friend or a family member to read and analyze your work. Also, you can order editing services in case your paper needs to be perfectly polished so that you can submit an ideal essay and get an excellent grade.

As these steps are simple to follow, you will not have any problems coping with an essay on time. Try the whole procedure at least once, and you will not have to use any other tips preparing an essay paper during your studies!

Where did microglia originate from?

In summary, microglia are CNS-resident macrophages that originate from primitive progenitors in the yolk sac and migrate into the CNS during early embryogenesis. Their proliferation and differentiation is dependent on a set of transcription factors and growth factor receptors (including PU.

When was the microglia discovered?

Highlights. Microglia were first described by the Spanish researcher Pío del Río-Hortega in 1919. Río-Hortega’s discoveries identified and defined the three types of glial cells of the CNS: astrocytes, oligodendrocytes, and microglia.

Where is microglia located?

central nervous system
Microglia are a type of neuroglia (glial cell) located throughout the brain and spinal cord. Microglia account for 10–15% of all cells found within the brain. As the resident macrophage cells, they act as the first and main form of active immune defense in the central nervous system (CNS).

What is a microglia?

Microglia represent a specialized population of macrophages-like cells in the central nervous system (CNS) considered immune sentinels that are capable of orchestrating a potent inflammatory response.

Are microglia derived from macrophages?

(a) Resident microglia originate from yolk sac macrophages that repopulate CNS parenchyma during early development and are self-renewed locally, independent from bone marrow-derived monocytes, by proliferation of primitive progenitors.

Who discovered the microglia?

Pío del Río-Hortega
Microglia, discovered in 1919 by Pío del Río-Hortega, turned 100 years old in 2019. For a long time, microglial research has been hindered by the misconception that these cells solely functioned as macrophages involved in the neuroinflammatory response.

What is microglia function?

Microglia regulate brain development primarily through two routes: the release of diffusible factors and phagocytosis. Microglia phagocytize many products in the brain, including synaptic elements, living cells, dying or dead cells, and axons.

Why are microglial cells important?

Microglial cells are a specialised population of macrophages that are found in the central nervous system (CNS). They remove damaged neurons and infections and are important for maintaining the health of the CNS.

What is the difference between macrophages and microglia?

Microglial cells scavenge the brain tissue for pathogens, plaques, damaged neurons and synapses, and any other changes that might damage the CNS….Macrophages and Microglia – Same but Different!

Macrophages Microglia
First line of defense? Macrophages are not the first line of defense. Microglia are the first line of defense in the CNS.

Which cells give rise to microglia?

Microglia arise predominantly from YS-derived macrophages (Fig. 1) (Ginhoux et al. 2010; Kierdorf et al. 2013a), whereas Langerhans cells originate mainly from FL-derived monocytes, but retain a detectable YS-derived macrophage (MF) component (Hoeffel et al.

How do microglia protect the brain?

Microglial functions are especially crucial during brain development, when they help young neurons grow, and ensure the right connections are made between neurons. Through a procedure called pruning, microglia eat connections between neurons, maintaining strong ones while eliminating weaker or unnecessary ones.

How do microglial cells work?

For many years the function of microglia was unclear. However, today it is known that these cells mediate immune responses in the central nervous system by acting as macrophages, clearing cellular debris and dead neurons from nervous tissue through the process of phagocytosis (cell eating).

What is the history of microglia?

The cell staining techniques in the 1880s showed that microglia are related to macrophages. The activation of microglia and formation of ramified microglial clusters was first noted by Victor Babeş while studying a rabies case in 1897.

What are microglial progenitors and where do they come from?

Microglial progenitors with a high proliferative potential in the embryonic and adult mouse brain. Proc Natl Acad Sci 88: 1541–1545. Alliot F, Godin I, Pessac B. 1999. Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain.

What role do microglia play in the development of the CNS?

First, the conservation of primitive macrophages and their YS derivation, both throughout evolution and across diverse species, suggests that microglia play an important physiological role in the development of the CNS.

What is a microglial cell?

Del Rio-Hortega introduced the term “microglial cell” to describe the non-neuronal, non-astrocytic third element as distinct from neurectodermal oligodendroglia or oligodendrocytes (Rio-Hortega, 1939) (For historic review see Rezaie and Male, 2002 ).