What are the side effects of daptomycin?
More common
- Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site.
- difficulty having a bowel movement.
What should I monitor for daptomycin?
Daptomycin is given parenterally once a day. Over 90% is bound to serum protein. Dosing is adjusted for renal failure. Because daptomycin can cause reversible skeletal myopathy, patients should be monitored for muscle pain or weakness, and serum creatine kinase levels should be checked weekly.
Why is daptomycin restricted?
The Antimicrobial Restrictions are in place due to concerns regarding a variety of issues: off-label use; the need for increased dosage for patients with bacteremia/endocarditis or other serious infections due to gram-positive pathogens; contraindication for daptomycin use in patients with pneumonia.
Is daptomycin safe?
Daptomycin was safe and well tolerated. The frequency, distribution, and severity of AEs were similar for daptomycin and standard therapy. Discontinuations due to AEs were uncommon, and there were no deaths assessed as related to study medication.
Is daptomycin hard on kidneys?
This medicine may cause serious skin reactions, including drug reaction with eosinophilia and systemic symptoms (DRESS), which can damage organs, including the liver, kidney, or heart.
Does daptomycin need renal adjustment?
Renal Dosing Daptomycin is eliminated primarily by the kidneys; therefore, a modification of CUBICIN dosage is recommended for patients with CLCR <30 mL/min, including patients receiving hemodialysis or continuous ambulatory peritoneal dialysis (CAPD).
Is daptomycin nephrotoxic?
Our analysis suggests that daptomycin is a less nephrotoxic agent than vancomycin. These results are in agreement with previous observations [23, 24].
When do we not use daptomycin?
Daptomycin should not be used to treat pneumonia. This is due to the fact that daptomycin is inhibited by surfactant (Silverman et al 2005).
Does daptomycin affect the liver?
Conclusion: Although hepatic abnormalities caused by daptomycin are rare, a handful of cases with daptomycin-induced liver injury have been reported in the literature. Of note, in most cases, patients on daptomycin therapy developed liver damage with elevations in CK levels.
Can daptomycin cause Steven Johnson?
Daptomycin has also been implicated to cause some hypersensitivity reactions but the incidence of SJS has been attributed more to ceftaroline. In addition, ceftaroline has been shown to cause agranulocytosis and neutropenia in several reports, especially with prolonged use.